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NFE2L2(V32T) Protein

NFE2L2(V32T) Mutant
5/5

¥347.00

货号:10452

规格: 100 微升

库存状态:In Stock

           产品描述          
产品名称:   NFE2L2(V32T) 突变蛋白
货号:   10452
产品全名:    NFE2L2 Protein V32T 突变蛋白
基因符号  Nuclear factor (erythroid-derived 2)-like 2, Nrf2
Source:   Human, recombinant full length, His6-tag
Expression 种属反应性:   E. coli
分子量:   26 kDa
纯化:   >99% by SDS-PAGE
Introduction:   NFE2L2 protein is encoded by NFE2L2 gene. It is a basic leucine zipper protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.
Amino Acid Sequence  (1-170)
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGTSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDAL
YFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVA
Properties
Physical Appearance (form):   Dissolved in 20mM Tris-HCl, pH8.0, 150mM NaCl.
Physical Appearance (form):   White or clear
Concentration:   1 mg/mL
Storage:    -80°C
Preparation Instructions:   
Adding of 10 mM β-mercaptoethanol or 1 mM DTT into the solution to protect the protein is recommended and using of non-ionic detergents such as n-Dodecyl β-D-maltoside (DoDM) or polyethylene detergents (e.g. C12E10) also help to stabilize the protein. Avoid repeated freezing and thawing.


The purity of His-tagged NFE2L2 V32T was determined by SDS-PAGE and Coomassie Brilliant Blue Staining.
References:   
1. Moi P et al., Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9926-30.
2. Gold R et al., N. Engl. J. Med. 367 (12): 1098-107.

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