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RhoA Pull-Down Activation Assay Kit

RhoA Pull-Down Assay Kit
5/5

¥6,800.00

货号:80601

规格: 30 Assays

库存状态:In Stock

           产品描述          

RhoA Pull-Down Activation Assay Kit

Cat. # 80601

Introduction

A. Background
Small GTPases are a super-family of cellular signaling regulators. RhoA belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of RhoA, and the hydrolysis of GTP to GDP renders it inactive.
Currently the activation of RhoA proteins is assayed with the binding of GTP-bound RhoA to the p21-binding domain (PBD) of p21-activated protein kinase (PAK). This method is based on the observation that the active, GTP-bound RhoA could bind to the PBD of PAK. However, the reproducibility of this method is poor. This is partially due to the relatively quick hydrolysis of GTP to GDP during the assay procedure, and the low binding affinity of PBD to RhoA-GTP.
The RhoA Activation Assay Kit is based on the configuration-specific monoclonal antibody that specifically recognizes RhoA-GTP, but not RhoA-GDP. Given the high affinity of monoclonal antibodies to their antigens, the activation assay could be performed in a much shorter time. This assay provides the reliable results with consistent reproducibility.
The anti-RhoA-GTP monoclonal antibody can also be used to monitor the activation of RhoA in cells and in tissues by immunohistochemistry.
B. Assay Principle
The RhoA Activation Assay Kit uses configuration-specific anti-RhoA-GTP Mouse monoclonal antibody to measure RhoA-GTP levels in cell extracts or in vitro GTPγS loading RhoA activation assays. Anti-RhoA-GTP mouse monoclonal antibody is first incubated with cell lysates containing RhoA-GTP. Next, the GTP-bound RhoA is pulled down by protein A/G agarose. Finally, the precipitated RhoA-GTP is detected through immunoblot analysis using Anti-RhoA Rabbit Polyclonal Antibody.
C. Kit Components
1. Anti-RhoA-GTP Mouse Monoclonal Antibody (Cat. # 26904): 30 µL (1 mg/ml) in PBS, pH 7.4, containing 50% glycerol. This antibody specifically recognizes RhoA-GTP from all vertebrates.
2. Protein A/G Agarose (Cat. # 30301): 600 µL of 50% slurry.
3. 5X Assay/Lysis Buffer (Cat. # 30302): 30 mL of 250 mM Tris-HCl, pH 8, 750 mM NaCl, 50 mM MgCl2, 5 mM EDTA, 5% Triton X-100.
4. Anti-RhoA Rabbit Polyclonal Antibody (Cat. # 21017): 50 µL (1 mg/mL) in PBS, pH 7.4, contained 50% glycerol.
5. 100X GTPγS (Cat. # 30303): 50 µl at 10 mM, use 5 µL of GTPγS for  GTP-labeling of 0.5 mL of cell lysate.
6. 100X GDP (Cat. # 30304): 50 µl at 100 mM, use 5 µL of GDP for GDP-labeling of 0.5 mL of cell lysate.
7. HRP-Goat Anti-Rabbit IgG (Cat. # 29002): 50 µL (0.4 mg/mL) in PBS, pH 7.4, contained 50% glycerol.
D. Materials Needed but Not Supplied
1. Stimulated and non-stimulated cell lysates
2. Protease inhibitors
3. 4 °C tube rocker or shaker
4. 0.5 M EDTA at pH 8.0
5. 1.0 M MgCl2
6. 2X reducing SDS-PAGE sample buffer
7. Electrophoresis and immunoblotting systems
8. Immunoblotting wash buffer such as TBST (10 mM Tris-HCl, pH 7.4, 0.15 M NaCl, 0.05%  Tween-20)
9. Immunoblotting blocking buffer (TBST containing 5% Non-fat Dry Milk or 3% BSA)
10. ECL Detection Reagents
E. Example Results
The following figure demonstrates example results seen with the RhoA Activation Assay Kit. For reference only.
RhoA Activation Assay Kit RhoA Activation Assay. MEF cells were treated with (lane 2) or without (lane 1) PDGF. Cell lysates were incubated with an anti-RhoA-GTP monoclonal antibody (Cat. # 26904) (top panel). The precipitated RhoA-GTP was immunoblotted with an anti-RhoA rabbit polyclonal antibody (Cat # 21017). The bottom panel shows the Western blot with anti-RhoA of the cell lysates used (5% of that used in the top panel).

Assay Procedure

A. Reagent Preparation
1X Assay/Lysis Buffer: Mix the 5X Stock (Cat. # 30302) briefly and dilute with deionized water to make 1X buffer. Just prior to usage, add protease inhibitors such as 1 mM PMSF, 10 µg/mL leupeptin, and 10 µg/mL aprotinin.
B. Sample Preparation
Adherent Cells
1. Culture cells (one 10-cm plate, ~107 cells) to approximately 80-90% confluence. Stimulate the cells with activator or inhibitor as desired.
2. Aspirate the culture media and wash twice with ice-cold PBS.
3. Completely remove the final PBS wash and add ice-cold 1X Assay/Lysis Buffer (See Reagent Preparation) to the cells (0.5-1 mL per 10 cm tissue culture plate).
4. Place the culture plates on ice for 10-20 minutes.
5. Detach the cells from the plates by scraping with a cell scraper.
6. Transfer the lysates to appropriate size tubes and place on ice.
7. If nuclear lysis occurs, the cell lysates may become viscous and difficult to pipette. If this occurs, lysates can be passed through a 27½-gauge syringe needle 3-4 times to shear the genomic DNA.
8. Clear the lysates by centrifuging at 12,000 x g and 4°C for 10 minutes.
9. Collect the supernatant and store the sample (~1-2 mg of total protein) on ice for immediate use, or snap freeze and store at -70°C for future use.
Suspension Cells
1. Culture cells and stimulate with activator or inhibitor as desired.
2. Perform a cell count and then pellet the cells through centrifugation.
3. Aspirate the culture media and wash twice with ice-cold PBS.
4. Completely remove the final PBS wash and add ice-cold 1X Assay/Lysis Buffer (See Reagent Preparation) to the cell pellet (0.5-1 mL per 107 cells).
5. Lyse the cells by repeated pipetting.
6. Transfer the lysates to appropriate size tubes and place them on ice.
7. If nuclear lysis occurs, the cell lysates may become viscous and difficult to pipette. If this occurs, lysates can be passed through a 27½-gauge syringe needle 3-4 times to shear the genomic DNA.
8. Clear the lysates by centrifuging at 12,000 x g and 4°C for 10 minutes.
9. Collect the supernatant and store sample on ice for immediate use, or snap freeze and store at -70°C for future use.
C. In vitro GTPγS/GDP Protein for Positive and Negative controls
Note: In vivo stimulation of cells will activate approximately 10% of the available RhoA, whereas in vitro GTPγS protein loading will activate nearly 90% of RhoA.
1. Aliquot 0.5 mL of cell extract (or 1 µg of purified RhoA protein) into two microcentrifuge tubes.
2. To each tube, add 20 µL of 0.5 M EDTA (final concentration of 20 mM).
3. Add 5 µL of 100 X GTPγS (Cat. # 30303) to the first tube as a positive control.
4. Add 5 µL of 100 X GDP (Cat. # 30304) to the second tube as a negative control.
5. Incubate both tubes at 30°C for 30 minutes with agitation.
6. Stop loading by placing the tubes on ice and adding 32.5 µL of 1 M MgCl2 (final concentration of 60 mM).
D. Affinity Precipitation of Activated G Protein
1. Aliquot 0.5-1 mL of cell lysates (about 1 mg of total cellular protein) to a microcentrifuge tube.
2. Adjust the volume to 1 mL with 1X Assay/Lysis Buffer (See Reagent Preparation).
3. Add 1 µL anti-RhoA-GTP antibody (Cat. # 26904).
4. Prepare the protein A/G Agarose bead slurry (Cat. # 30301) by resuspending through vertexing or titrating.
5. Quickly add 20 µL of resuspended bead slurry to above tube.
6. Incubate the tube at 4°C for 1 hour with gentle agitation.
7. Pellet the beads through centrifugation at 5,000 x g for 1 min.
8. Aspirate and discard the supernatant (making sure not to disturb or remove the bead pellet).
9. Wash the beads 3 times with 0.5 mL of 1X Assay/Lysis Buffer, centrifuging and aspirating each time.
10. After the third wash, pellet the beads through centrifugation and carefully remove all the supernatant.
11. Resuspend the bead pellet in 20 µL of 2X reducing SDS- PAGE sample buffer.
12. Boil the sample for 5 minutes.
13. Centrifuge it at 5,000 x g for 10 seconds.
E. Western Blot Analysis
1. Load 15 µL/well of pull-down supernatant to a polyacrylamide gel (17%). It is recommended to include a pre-stained MW standard (as an indicator of a successful transfer in step 3 below).
2. Perform SDS-PAGE following the manufacturer’s instructions.
3. Transfer the gel proteins to a PVDF or nitrocellulose membrane following the manufacturer’s instructions.
Note: Steps 4-11 are at room temperature with agitation
4. Following electroblotting, immerse the PVDF membrane in 100% Methanol for 15 seconds, and then allow it to dry at room temperature for 5 minutes.
Note: If Nitrocellulose is used instead of PVDF, step 4 Should be skipped.
5. Block the membrane with 5% non-fat dry milk or 3% BSA in TBST for 1 hr at room temperature with constant agitation.
6. Wash the blotted membrane three times with TBST, 5 minutes each time.
7. Incubate the membrane with Anti-RhoA Rabbit Polyclonal Antibody (Cat. # 21017), which is freshly diluted 1:50~500 (depending on the amount of RhoA proteins in your sample) in 5% non-fat dry milk or 3% BSA in TBST, for 1-2 hr at room temperature with constant agitation or at 4°C overnight.
8. Wash the blotted membrane three times with TBST, 5 minutes each time.
9. Incubate the membrane with a secondary antibody (Cat. # 29002), which is freshly diluted 1:1000 in 5% non-fat dry milk or 3% BSA in TBST, for 1 hr at room temperature with constant agitation.
10. Wash the blotted membrane three times with TBST, 5 minutes each time.
11. Use the detection method of your choice such as ECL.
           引用文献          

<table>
<tbody>
<tr><td><strong>001.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/37225434/” target=”_blank” rel=”noopener”>Ogt Deficiency Induces Abnormal Cerebellar Function and Behavioral Deficits of Adult Mice through Modulating RhoA/ROCK Signaling</a><br/>J Neurosci. 2023 &emsp;&emsp;PMID:&nbsp;37225434</td><tr/>
<tr><td><strong>002.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36284029/” target=”_blank” rel=”noopener”>Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis</a><br/>J Cell Commun Signal. 2023 &emsp;&emsp;PMID:&nbsp; 36477766</td><tr/>
<tr><td><strong>003.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967383/” target=”_blank” rel=”noopener”>Reducing GEF-H1 Expression Inhibits Renal Cyst Formation, Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis</a><br/>Int J Mol Sci. 2023 &emsp;&emsp;PMID:&nbsp; 36834937</td><tr/>
<tr><td><strong>004.&emsp;</strong><a href=”https://www.researchsquare.com/article/rs-2508957/v1″ target=”_blank” rel=”noopener”>Junctional Force Patterning drives both Positional and Orientational Order in Auditory Epithelia</a><br/>Research Square. 2023 &emsp;&emsp;PMID:&nbsp;</td><tr/>
<tr><td><strong>005.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36379207/” target=”_blank” rel=”noopener”>CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition</a><br/>Cancer Cell. 2022&emsp;&emsp;PMID:&nbsp;36379207</td><tr/>
<tr><td><strong>006.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/35460881/” target=”_blank” rel=”noopener”>BKM120 alters the migration of doublecortin-positive cells in the dentate gyrus of mice</a><br/>Pharmacol Res. 2022&emsp;&emsp;PMID:&nbsp;35460881</td><tr/>
<tr><td><strong>007.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36323321/” target=”_blank” rel=”noopener”>Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity</a><br/>Neuron. 2022&emsp;&emsp;PMID:&nbsp;36323321</td><tr/>
<tr><td><strong>008.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36284029/” target=”_blank” rel=”noopener”>Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis</a><br/>J Cell Commun Signal. 2022&emsp;&emsp;PMID:&nbsp;36284029</td><tr/>
<tr><td><strong>009.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36265882/” target=”_blank” rel=”noopener”>Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor</a><br/>Eur Respir J. 2022&emsp;&emsp;PMID:&nbsp;36265882</td><tr/>
<tr><td><strong>010.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/36001358/” target=”_blank” rel=”noopener”>ARHGEF15 in Sertoli cells contributes to germ cell development and testicular immune privilege</a><br/>Biol Reprod. 2022&emsp;&emsp;PMID:&nbsp;36001358</td><tr/>
<tr><td><strong>011.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/35074515/” target=”_blank” rel=”noopener”>Rac1 mediates cadherin-11 induced cellular pathogenic processes in aortic valve calcification</a><br/>Cardiovasc Pathol. 2022&emsp;&emsp;PMID:&nbsp;35074515</td><tr/>
<tr><td><strong>012.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/34528082/” target=”_blank” rel=”noopener”>Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation</a><br/>Cardiovasc Res. 2022&emsp;&emsp;PMID:&nbsp;34528082</td><tr/>
<tr><td><strong>013.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/35306138/” target=”_blank” rel=”noopener”>IGF2BP2 promotes gastric cancer progression by regulating the IGF1R-RhoA-ROCK signaling pathway</a><br/>Cell Signal. 2022&emsp;&emsp;PMID:&nbsp;35306138</td><tr/>
<tr><td><strong>014.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/35367887/” target=” blank” rel=”noopener”>Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway</a><br/>Ecotoxicol Environ Saf. 2022&emsp;&emsp;PMID:&nbsp;35367887</td><tr/>
<tr><td><strong>015.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308268/” target=”_blank” rel=”noopener”>ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42</a><br/>J Exp Clin Cancer Res. 2022&emsp;&emsp;PMID:&nbsp;35869555</td><tr/>
<tr><td><strong>016.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051212/” target=”_blank” rel=”noopener”>Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma</a><br/>Nat Commun. 2022&emsp;&emsp;PMID:&nbsp;35484119</td><tr/>
<tr><td><strong>017.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993752″ target=”_blank” rel=”noopener”>Modulation of Mechanical Stress Mitigates Anti-Dsg3 Antibody-Induced Dissociation of Cell-Cell Adhesion</a><br/>Adv Biol (Weinh). 2021&emsp;&emsp;PMID:&nbsp;33724731</td><tr/>
<tr><td><strong>018.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576704/” target=”_blank” rel=”noopener”>MYO1B enhances colorectal cancer metastasis by promoting the F-actin rearrangement and focal adhesion assembly via RhoA/ROCK/FAK signaling</a><br/>Ann Transl Med. 2021&emsp;&emsp;PMID:&nbsp;34790749</td><tr/>
<tr><td><strong>019.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213848/” target=”_blank” rel=”noopener”>Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization.inhibits cell migration and re-epithelialization of non-healing wounds</a><br/>Commun Biol. 2021&emsp;&emsp;PMID:&nbsp;34145387</td><tr/>
<tr><td><strong>020.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276982/” target=”_blank” rel=”noopener”>Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve</a><br/>Development. 2021&emsp;&emsp;PMID:&nbsp;34086041</td><tr/>
<tr><td><strong>021.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/33472844/” target=”_blank” rel=”noopener”>Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor</a><br/>Development. 2021&emsp;&emsp;PMID:&nbsp; 33472844</td><tr/>
<tr><td><strong>022.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/33792148/” target=”_blank” rel=”noopener”>ROCK inhibitor attenuates carbon blacks-induced pulmonary fibrosis in mice via Rho/ROCK/NF-kappa B pathway</a><br/>Environ Toxicol. 2021&emsp;&emsp;PMID:&nbsp;33792148</td><tr/>
<tr><td><strong>023.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703258/” target=”_blank” rel=”noopener”>BBS7–SHH Signaling Activity Regulates Primary Cilia for Periodontal Homeostasis</a><br/>Front Cell Dev Biol. 2021&emsp;&emsp;PMID:&nbsp;34957122</td><tr/>
<tr><td><strong>024.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081905/” target=”_blank” rel=”noopener”>Benzo(a)pyrene Enhanced Dermatophagoides Group 1 (Der f 1)-Induced TGFß1 Signaling Activation Through the Aryl Hydrocarbon Receptor-RhoA Axis in Asthma</a><br/>Front Immunol. 2021&emsp;&emsp;PMID:&nbsp;33936062</td><tr/>
<tr><td><strong>025.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000060/” target=”_blank” rel=”noopener”>Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease</a><br/>Int J Mol Sci. 2021&emsp;&emsp;PMID:&nbsp;33799579</td><tr/>
<tr><td><strong>026.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/34166723/” target=” blank” rel=”noopener”>Modulation of proteoglycan receptor regulates RhoA/CRMP2 pathways and promotes axonal myelination</a><br/>Neurosci Lett. 2021&emsp;&emsp;PMID:&nbsp;34166723</td><tr/>
<tr><td><strong>027.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/34166723/” target=” blank” rel=”noopener”>Modulation of proteoglycan receptor regulates RhoA/CRMP2 pathways and promotes axonal myelination</a><br/>Neurosci Lett. 2021&emsp;&emsp;PMID:&nbsp;34166723</td><tr/>
<tr><td><strong>028.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423926″ target=”_blank” rel=”noopener”>Decreased Level of Exosomal miR-5121 Released from Microglia Suppresses Neurite Outgrowth and Synapse Recovery of Neurons Following Traumatic Brain Injury</a><br/>Neurotherapeutics. 2021&emsp;&emsp;PMID:&nbsp;33475953</td><tr/>
<tr><td><strong>029.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/34600176/” target=” blank” rel=”noopener”>The role of daurisoline treatment in hepatocellular carcinoma: Inhibiting vasculogenic mimicry formation and enhancing sensitivity to sorafenib</a><br/>Phytomedicine. 2021&emsp;&emsp;PMID:&nbsp;34600176</td><tr/>
<tr><td><strong>030.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058714/” target=”_blank” rel=”noopener”>MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer</a><br/>Theranostics. 2021&emsp;&emsp;PMID:&nbsp;33897882</td><tr/>
<tr><td><strong>031.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/32903032/” target=”_blank” rel=”noopener”>Spatial locations of certain enzymes and transporters within preinvasive ductal epithelial cells predict human breast cancer recurrences</a><br/>Am J Physiol Cell Physiol. 2020&emsp;&emsp;PMID:&nbsp;32903032</td><tr/>
<tr><td><strong>032.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/34210880/” target=” blank” rel=”noopener”>Astrocytes close the critical period for visual plasticity</a><br/>bioRxiv. 2020&emsp;&emsp;PMID:&nbsp;34210880</td><tr/>
<tr><td><strong>033.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548225″ target=”_blank” rel=”noopener”>ANLN Directly Interacts with RhoA to Promote Doxorubicin Resistance in Breast Cancer Cells</a><br/>Cancer Manag Res. 2020&emsp;&emsp;PMID:&nbsp;33116832</td><tr/>
<tr><td><strong>034.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/32579923/” target=”_blank” rel=”noopener”>Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration</a><br/>Cell Rep. 2020&emsp;&emsp;PMID:&nbsp;32579923</td><tr/>
<tr><td><strong>035.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/33378678/” target=” blank” rel=”noopener”>QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis</a><br/>Cell Rep. 2020&emsp;&emsp;PMID:&nbsp;33378678</td><tr/>
<tr><td><strong>036.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021812/” target=”_blank” rel=”noopener”>Serotonin 5-HT4 receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin</a><br/>Commun Biol. 2020&emsp;&emsp;PMID:&nbsp;32060357</td><tr/>
<tr><td><strong>037.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/32428455/” target=” blank” rel=”noopener”>Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis</a><br/>Dev Cell. 2020&emsp;&emsp;PMID:&nbsp;32428455</td><tr/>
<tr><td><strong>038.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928066/” target=”_blank” rel=”noopener”>europeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA Activation</a><br/>Front Cell Dev Biol. 2020&emsp;&emsp;PMID:&nbsp;33681186</td><tr/>
<tr><td><strong>039.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299196″ target=”_blank” rel=”noopener”>Arhgef5 Binds a-Dystrobrevin 1 and Regulates Neuromuscular Junction Integrity</a><br/>Front Mol Neurosci. 2020&emsp;&emsp;PMID:&nbsp;32587503</td><tr/>
<tr><td><strong>040.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335183/” target=”_blank” rel=”noopener”>Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafishs</a><br/>Nat Commun. 2020&emsp;&emsp;PMID:&nbsp;32620775</td><tr/>
<tr><td><strong>041.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020796″ target=”_blank” rel=”noopener”>Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis</a><br/>Neurobiol Dis. 2020&emsp;&emsp;PMID:&nbsp;31931138</td><tr/>
<tr><td><strong>042.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549670/” target=”_blank” rel=”noopener”>Acute compressive stress activates RHO/ROCK-mediated cellular processes</a><br/>Small GTPases. 2020&emsp;&emsp;PMID:&nbsp;29455593</td><tr/>
<tr><td><strong>043.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246394/” target=” blank” rel=”noopener”>Actin Alpha 2 (ACTA2) Downregulation Inhibits Neural Stem Cell Migration through Rho GTPase Activation</a><br/>Stem Cells Int. 2020&emsp;&emsp;PMID:&nbsp;32508931</td><tr/>
<tr><td><strong>044.&emsp;</strong><a href=”https://www.jikm.or.kr/journal/view.php?doi=10. 22246/jikm. 2020.41.4.553″ target=”_blank” rel=”noopener”>Mitigative Effect of Sipjeondaebo-tang on RhoA Activation in Cold-Exposed Vascular Cells</a><br/>The Journal of Internal Korean Medicine. 2020&emsp;&emsp;PMID:&nbsp;https://www.jikm.or.kr/journal/view.php?doi=10. 22246/jikm. 2020.41.4.553</td><tr/>
<tr><td><strong>045.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787190/” target=”_blank” rel=”noopener”>Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways</a><br/>Cell Death & Disease&#44;2019&emsp;&emsp;PMID:&nbsp;31601793</td><tr/>
<tr><td><strong>046.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554403/” target=”_blank” rel=”noopener”>The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood–testis barrier and results in hypospermatogenesis</a><br/>Cell Death Dis. 2019&emsp;&emsp;PMID:&nbsp;31171774</td><tr/>
<tr><td><strong>047.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/31530101/” target=” blank” rel=”noopener”>BK<sub>Ca</sub> compensates impaired coronary vasoreactivity through RhoA/ROCK pathway in hind-limb unweighted rats</a><br/>FASEB J. 2019&emsp;&emsp;PMID:&nbsp; 31530101</td><tr/>
<tr><td><strong>048.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30374974/” target=” blank” rel=”noopener”>The role of sema4D in vasculogenic mimicry formation in non-small cell lung cancer and the underlying mechanisms</a><br/>Int J Cancer. 2019&emsp;&emsp;PMID:&nbsp; 30374974</td><tr/>
<tr><td><strong>049.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401351/” target=”_blank” rel=”noopener”>RhoA/ROCK Signaling Modulates Lineage Commitment of Mesenchymal Stem Cells in Asthma through Lef1</a><br/>J Allergy Clin Immunol. 2019&emsp;&emsp;PMID:&nbsp;30194990</td><tr/>
<tr><td><strong>050.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802501/” target=”_blank” rel=”noopener”>Claudin-2 suppresses GEF-H1.RHOA.and MRTF.thereby impacting proliferation and profibrotic phenotype of tubular cells</a><br/>J Biol Chem. 2019&emsp;&emsp;PMID:&nbsp;31481470</td><tr/>
<tr><td><strong>051.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30609027/” target=”_blank” rel=”noopener”>Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia</a><br/>J Cell Physiol. 2019&emsp;&emsp;PMID:&nbsp;30609027</td><tr/>
<tr><td><strong>052.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30589940/” target=” blank” rel=”noopener”>AMPA receptors modulate the reorganization of F-actin in Bergmann glia cells through the activation of RhoA</a><br/>J Neurochem. 2019&emsp;&emsp;PMID:&nbsp;30589940</td><tr/>
<tr><td><strong>053.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/31339573/” target=” blank” rel=”noopener”>Inhibition of Notch1 signaling promotes neuronal differentiation and improves functional recovery in spinal cord injury through suppressing the activation of Ras homolog family member A</a><br/>J Neurochem. 2019&emsp;&emsp;PMID:&nbsp;31339573</td><tr/>
<tr><td><strong>054.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824444/” target=”_blank” rel=”noopener”>miR-511-3p protects against cockroach allergen-induced lung inflammation by antagonizing CCL2</a><br/>JCI Insight. 2019&emsp;&emsp;PMID:&nbsp;31536479</td><tr/>
<tr><td><strong>055.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643059″ target=”_blank” rel=”noopener”>Simvastatin pretreatment ameliorates t-PA-induced hemorrhage transformation and MMP-9/TIMP-1 imbalance in thromboembolic cerebral ischemic rats</a><br/>Neuropsychiatr Dis Treat. 2019&emsp;&emsp;PMID:&nbsp;31410004</td><tr/>
<tr><td><strong>056.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884968/” target=” blank” rel=”noopener”>P120-Catenin And Its Phosphorylation On Tyr228 Inhibits Proliferation And Invasion In Colon Adenocarcinoma Cells</a><br/>Onco Targets Ther. 2019&emsp;&emsp;PMID:&nbsp;32063714</td><tr/>
<tr><td><strong>057.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30846413/” target=”_blank” rel=”noopener”>Increased expression of GEF-H1 promotes colon cancer progression by RhoA signaling</a><br/>Pathology – Research and Practice. 2019&emsp;&emsp;PMID:&nbsp;30846413</td><tr/>
<tr><td><strong>058.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/31028904/” target=”_blank” rel=”noopener”>12(S)-Hydroxyeicosatetraenoic acid downregulates monocyte-derived macrophage efferocytosis: New insights in atherosclerosis</a><br/>Pharmacol Res. 2019&emsp;&emsp;PMID:&nbsp;31028904</td><tr/>
<tr><td><strong>059.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/31321704/” target=” blank” rel=”noopener”>Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer’s disease</a><br/>Protein Cell. 2019&emsp;&emsp;PMID:&nbsp;31321704</td><tr/>
<tr><td><strong>060.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416270/” target=”_blank” rel=”noopener”>Profibrotic epithelial phenotype: a central role for MRTF and TAZ</a><br/>Sci Rep. 2019&emsp;&emsp;PMID:&nbsp;30867502</td><tr/>
<tr><td><strong>061.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690958/” target=”_blank” rel=”noopener”>Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis</a><br/>Scientific Reports. 2019&emsp;&emsp;PMID:&nbsp;31406143</td><tr/>
<tr><td><strong>062.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866437/” target=”_blank” rel=”noopener”>RhoA increases ASIC1a plasma membrane localization and calcium influx in pulmonary arterial smooth muscle cells following chronic hypoxia</a><br/>Am J Physiol Cell Physiol. 2018&emsp;&emsp;PMID:&nbsp;29070491</td><tr/>
<tr><td><strong>063.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260585″ target=”_blank” rel=”noopener”>E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking</a><br/>Biol Psychiatry. 2018&emsp;&emsp;PMID:&nbsp;30158054</td><tr/>
<tr><td><strong>064.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29635128/” target=” blank” rel=”noopener”>Naringin attenuates MLC phosphorylation and NF-?B activation to protect sepsis-induced intestinal injury via RhoA/ROCK pathway</a><br/>Biomed Pharmacother. 2018&emsp;&emsp;PMID:&nbsp;29635128</td><tr/>
<tr><td><strong>065.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200100/” target=”_blank” rel=”noopener”>Inhibition of RhoA reduces propofol-mediated growth cone collapse.axonal transport impairment.loss of synaptic connectivity.and behavioural deficits</a><br/>Br J Anaesth. 2018&emsp;&emsp;PMID:&nbsp;29576115</td><tr/>
<tr><td><strong>066.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29444209/” target=” blank” rel=”noopener”>Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart</a><br/>Cardiovasc Res. 2018&emsp;&emsp;PMID:&nbsp;29444209</td><tr/>
<tr><td><strong>067.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924761/” target=”_blank” rel=”noopener”>The Rho GTPase Rnd1 inhibits epithelial–mesenchymal transition in hepatocellular carcinoma and is a favorable anti-metastasis target</a><br/>Cell Death Dis. 2018&emsp;&emsp;PMID:&nbsp;29706627</td><tr/>
<tr><td><strong>068.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30304669/” target=”_blank” rel=”noopener”>Social Isolation Induces Rac1-Dependent Forgetting of Social Memory</a><br/>Cell Rep. 2018&emsp;&emsp;PMID:&nbsp;30304669</td><tr/>
<tr><td><strong>069.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/30254631/” target=”_blank” rel=”noopener”>Fam65b Phosphorylation Relieves Tonic RhoA Inhibition During T Cell Migration</a><br/>Front Immunol. 2018&emsp;&emsp;PMID:&nbsp;30254631</td><tr/>
<tr><td><strong>070.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028505/” target=”_blank” rel=”noopener”>The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells</a><br/>J Exp Med. 2018&emsp;&emsp;PMID:&nbsp;29875261</td><tr/>
<tr><td><strong>071.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895035/” target=”_blank” rel=”noopener”>Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception</a><br/>J Neurosci. 2018&emsp;&emsp;PMID:&nbsp;29483280</td><tr/>
<tr><td><strong>072.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29393423/” target=”_blank” rel=”noopener”>COL1A1 promotes metastasis in colorectal cancer by regulating the WNT/PCP pathway</a><br/>Mol Med Rep. 2018&emsp;&emsp;PMID:&nbsp;29393423</td><tr/>
<tr><td><strong>073.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29751054/” target=” blank” rel=”noopener”>ß-Elemene Enhances GAP-43 Expression and Neurite Outgrowth by Inhibiting RhoA Kinase Activation in Rats with Spinal Cord Injury</a><br/>Neuroscience. 2018&emsp;&emsp;PMID:&nbsp;29751054</td><tr/>
<tr><td><strong>074.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036455/” target=”_blank” rel=”noopener”>MicroRNA-650 targets inhibitor of growth 4 to promote colorectal cancer progression via mitogen activated protein kinase signaling</a><br/>Oncol Lett. 2018&emsp;&emsp;PMID:&nbsp;30008936</td><tr/>
<tr><td><strong>075.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627671/” target=”_blank” rel=”noopener”>Anti-Inflammatory Activity in Colon Models Is Derived from Δ9-Tetrahydrocannabinolic Acid That Interacts with Additional Compounds in Cannabis Extracts</a><br/> Cannabis Cannabinoid Res. 2017&emsp;&emsp;PMID:&nbsp;29082314</td><tr/>
<tr><td><strong>076.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28670396/” target=”_blank” rel=”noopener”>Effects of chemerin/CMKLR1 in obesity-induced hypertension and potential mechanism</a><br/>Am J Transl Res. 2017&emsp;&emsp;PMID:&nbsp;28670396</td><tr/>
<tr><td><strong>077.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28743719/” target=” blank” rel=”noopener”>The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage</a><br/>Blood. 2017&emsp;&emsp;PMID:&nbsp;28743719</td><tr/>
<tr><td><strong>078.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747023/” target=”_blank” rel=”noopener”>Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin αv and integrin β3</a><br/>BMC Complement Altern Med. 2017&emsp;&emsp;PMID:&nbsp;29284478</td><tr/>
<tr><td><strong>079.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28559239/” target=” blank” rel=”noopener”>Escort cells generate a dynamic compartment for germline stem cell differentiation via combined Stat and Erk signalling</a><br/>Development. 2017&emsp;&emsp;PMID:&nbsp;28559239</td><tr/>
<tr><td><strong>080.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28947533/” target=” blank” rel=”noopener”>Rho differentially regulates the Hippo pathway by modulating the interaction between Amot and Nf2 in the blastocyst</a><br/>Development. 2017&emsp;&emsp;PMID:&nbsp;28947533</td><tr/>
<tr><td><strong>081.&emsp;</strong><a href=””https://pubmed.ncbi.nlm.nih.gov/27836552/”” target=””_blank”” rel=””noopener””>RhoA/ROCK pathway activity is essential for the correct localization of the germ plasm mRNAs in zebrafish embryos</a><br/>Dev Biol. 2017&emsp;&emsp;PMID:&nbsp;27836552</td><tr/>
<tr><td><strong>082.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732150/” target=”_blank” rel=”noopener”>Myosin 1g Contributes to CD44 Adhesion Protein and Lipid Rafts Recycling and Controls CD44 Capping and Cell Migration in B Lymphocytes</a><br/>Front Immunol. 2017&emsp;&emsp;PMID:&nbsp;29321775</td><tr/>
<tr><td><strong>083.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28887414/” target=”_blank” rel=”noopener”>Progressive polarity loss and luminal collapse disrupt tissue organization in carcinoma</a><br/>Genes Dev. 2017&emsp;&emsp;PMID:&nbsp;28887414</td><tr/>
<tr><td><strong>084.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/29016860/” target=” blank” rel=”noopener”>Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function</a><br/>Hum Mol Genet. 2017&emsp;&emsp;PMID:&nbsp;29016860</td><tr/>
<tr><td><strong>085.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687018/” target=”_blank” rel=”noopener”>The desmoplakin–intermediate filament linkage regulates cell mechanics</a><br/>Mol Biol Cell. 2017&emsp;&emsp;PMID:&nbsp;28495795</td><tr/>
<tr><td><strong>086.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27830358/” target=” blank” rel=”noopener”>Curcumin inhibits growth of human breast cancer cells through demethylation of DLC1 promoter</a><br/>Mol Cell Biochem. 2017&emsp;&emsp;PMID:&nbsp;27830358</td><tr/>
<tr><td><strong>087.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436224″ target=”_blank” rel=”noopener”>Induction of cell cycle arrest by increasing GTP-RhoA levels via Taxol-induced microtubule polymerization in renal cell carcinoma</a><br/>Mol Med Rep. 2017&emsp;&emsp;PMID:&nbsp;28487984</td><tr/>
<tr><td><strong>088.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28350093/” target=” blank” rel=”noopener”>Inhibitory effect of Angelica gigas on cold-induced RhoA activation in vascular cells</a><br/>Mol Med Rep. 2017&emsp;&emsp;PMID:&nbsp;28350093</td><tr/>
<tr><td><strong>089.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719012/” target=”_blank” rel=”noopener”>3D microniches reveal the importance of cell size and shape</a><br/>Nat Commun. 2017&emsp;&emsp;PMID:&nbsp;29213086</td><tr/>
<tr><td><strong>090.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28726800/” target=”_blank” rel=”noopener”>Role of Nicotinamide N-Methyltransferase in Dorsal Striatum in Cocaine Place Preference</a><br/>Neuropsychopharmacology. 2017.&emsp;&emsp;PMID:&nbsp;28726800</td><tr/>
<tr><td><strong>091.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584221/” target=”_blank” rel=”noopener”>EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway</a><br/>Oncotarget. 2017&emsp;&emsp;PMID:&nbsp;28881620</td><tr/>
<tr><td><strong>092.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625153/” target=”_blank” rel=”noopener”>inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide</a><br/>Pharmacol Res Perspect. 2017&emsp;&emsp;PMID:&nbsp;28971603</td><tr/>
<tr><td><strong>093.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224981/” target=”_blank” rel=”noopener”>GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary</a><br/>PLoS Genet. 2017&emsp;&emsp;PMID:&nbsp;28072828</td><tr/>
<tr><td><strong>094.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532275/” target=”_blank” rel=”noopener”>RhoA phosphorylation mediated by Rho/RhoA-associated kinase pathway improves the anti-freezing potentiality of murine hatched and diapaused blastocysts</a><br/>Sci Rep. 2017&emsp;&emsp;PMID:&nbsp;28751650</td><tr/>
<tr><td><strong>095.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/28078487/” target=”_blank” rel=”noopener”>The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia</a><br/>Sleep Breath. 2017&emsp;&emsp;PMID:&nbsp;28078487</td><tr/>
<tr><td><strong>096.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721977/” target=”_blank” rel=”noopener”>Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco-2 cells</a><br/>United European Gastroenterol J. 2017&emsp;&emsp;PMID:&nbsp;29238589</td><tr/>
<tr><td><strong>097.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26694899/” target=” blank” rel=”noopener”>Mutations of Cystic Fibrosis Transmembrane Conductance Regulator Gene Cause a Monocyte-Selective Adhesion Deficiency</a><br/>Am J Respir Crit Care Med. 2016&emsp;&emsp;PMID:&nbsp;26694899</td><tr/>
<tr><td><strong>098.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886818″ target=”_blank” rel=”noopener”>Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity</a><br/>Cell Discov. 2016&emsp;&emsp;PMID:&nbsp;27462462</td><tr/>
<tr><td><strong>099.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27670698/” target=”_blank” rel=”noopener”>Elongator controls cortical interneuron migration by regulating actomyosin dynamics</a><br/>Cell Res. 2016&emsp;&emsp;PMID:&nbsp;27670698</td><tr/>
<tr><td><strong>100.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25596714/” target=”_blank” rel=”noopener”>Curcumin inhibits LPA-induced invasion by attenuating RhoA/ROCK/MMPs pathway in MCF7 breast cancer cells</a><br/>Clin Exp Med. 2016&emsp;&emsp;PMID:&nbsp;25596714</td><tr/>
<tr><td><strong>101.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27188212/” target=” blank” rel=”noopener”>Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice</a><br/>Eur J Immunol. 2016&emsp;&emsp;PMID:&nbsp;27188212</td><tr/>
<tr><td><strong>102.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27651818/” target=”_blank” rel=”noopener”>Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells </a><br/>Evidence-Based Complementary and Alternative Medicine. 2016&emsp;&emsp;PMID:&nbsp;27651818</td><tr/>
<tr><td><strong>103.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919453″ target=”_blank” rel=”noopener”>Thiopurine Prodrugs Mediate Immunosuppressive Effects by Interfering with Rac1 Protein Function</a><br/>J Biol Chem. 2016&emsp;&emsp;PMID:&nbsp;27189938</td><tr/>
<tr><td><strong>104.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27218883/” target=”_blank” rel=”noopener”>The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination with Cell Polarization During Ameloblast Differentiation. </a><br/>J Bone Miner Res. 2016&emsp;&emsp;PMID:&nbsp;27218883</td><tr/>
<tr><td><strong>105.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27231093/” target=” blank” rel=”noopener”>VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells</a><br/>J Cell Sci. 2016&emsp;&emsp;PMID:&nbsp;27231093</td><tr/>
<tr><td><strong>106.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27167578/” target=” blank” rel=”noopener”>Alpha 7 nicotinic receptor coupling to heterotrimeric G proteins modulates RhoA activation.cytoskeletal motility.and structural growth</a><br/>J Neurochem. 2016&emsp;&emsp;PMID:&nbsp;27167578</td><tr/>
<tr><td><strong>107.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148245/” target=”_blank” rel=”noopener”>Converging.Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses</a><br/>J Neurosci. 2016&emsp;&emsp;PMID:&nbsp;27807170</td><tr/>
<tr><td><strong>108.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855537/” target=” blank” rel=”noopener”>RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix</a><br/>Nat Commun. 2016&emsp;&emsp;PMID:&nbsp;27126736</td><tr/>
<tr><td><strong>109.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400263/” target=”_blank” rel=”noopener”>RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics</a><br/>Nature Immunology&#44;2016&emsp;&emsp;PMID:&nbsp;27776107</td><tr/>
<tr><td><strong>110.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125678/” target=”_blank” rel=”noopener”>TGFbeta induces binucleation/polyploidization in hepatocytes through a src-Dependent cytokinesis failure</a><br/>PLoS One. 2016&emsp;&emsp;PMID:&nbsp;27893804</td><tr/>
<tr><td><strong>111.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977536/” target=”_blank” rel=”noopener”>p-Hydroxylcinnamaldehyde induces the differentiation of oesophageal carcinoma cells via the cAMP-RhoA-MAPK signalling pathway</a><br/>Scientific Reports . 2016&emsp;&emsp;PMID:&nbsp;27501997</td><tr/>
<tr><td><strong>112.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27269634/” target=”_blank” rel=”noopener”>Simulated Microgravity Disrupts Cytoskeleton Organization and Increases Apoptosis of Rat Neural Crest Stem Cells via Upregulating CXCR4 Expression and RhoA-ROCK1-p38 MAPK-p53 Signaling. </a><br/>Stem Cells Dev. 2016&emsp;&emsp;PMID:&nbsp;27269634</td><tr/>
<tr><td><strong>113.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/27396430/” target=”_blank” rel=”noopener”>Expression of G Protein-coupled Receptor 56 Is an Unfavorable Prognostic Factor in Osteosarcoma Patients </a><br/>Tohoku J Exp Med. 2016&emsp;&emsp;PMID:&nbsp;27396430</td><tr/>
<tr><td><strong>114.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473318/” target=” blank” rel=”noopener”>Netrin-1 promotes cell migration and invasion by down-regulation of BVES expression in human hepatocellular carcinoma</a><br/>Am J Cancer Res. 2015&emsp;&emsp;PMID:&nbsp;26101705</td><tr/>
<tr><td><strong>115.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905748/” target=”_blank” rel=”noopener”>Cyclic Mechanical Loading Is Essential for Rac1-Mediated Elongation and Remodeling of the Embryonic Mitral Valve</a><br/>Current Biology. 2015&emsp;&emsp;PMID:&nbsp;26725196</td><tr/>
<tr><td><strong>116.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26188246/” target=”_blank” rel=”noopener”>Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation </a><br/>Dev Biol. 2015&emsp;&emsp;PMID:&nbsp;26188246</td><tr/>
<tr><td><strong>117.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392599/” target=”_blank” rel=”noopener”>Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation</a><br/>Development. 2015&emsp;&emsp;PMID:&nbsp;25813538</td><tr/>
<tr><td><strong>118.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25724163/” target=”_blank” rel=”noopener”>Sodium Ferulate Reduces Portal Pressure Through Inhibition of RhoA/Rho-Kinase and Activation of Endothelial Nitric Oxide Synthase in Cirrhotic Rats</a><br/>Dig Dis Sci. 2015&emsp;&emsp;PMID:&nbsp;25724163</td><tr/>
<tr><td><strong>119.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279736/” target=”_blank” rel=”noopener”>Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease</a><br/>J Am Soc Nephrol. 2015&emsp;&emsp;PMID:&nbsp;24925721</td><tr/>
<tr><td><strong>120.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26290381/” target=” blank” rel=”noopener”>Tetraspanin-3 is an organizer of the multi-subunit Nogo-A signaling complex</a><br/>J Cell Sci. 2015&emsp;&emsp;PMID:&nbsp;26290381</td><tr/>
<tr><td><strong>121.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26392029/” target=” blank” rel=”noopener”>Dp63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts</a><br/>J Mol Cell Cardiol. 2015&emsp;&emsp;PMID:&nbsp;26392029</td><tr/>
<tr><td><strong>122.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25896910/” target=”_blank” rel=”noopener”>Creutzfeldt-Jakob Disease Subtype-Specific Regional and Temporal Regulation of ADP Ribosylation Factor-1-Dependent Rho/MLC Pathway at Pre-Clinical Stage</a><br/>J Mol Neurosci. 2015&emsp;&emsp;PMID:&nbsp;25896910</td><tr/>
<tr><td><strong>123.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25783411/” target=”_blank” rel=”noopener”>Kaempferol-3-O-rutinoside from Afgekia mahidoliae promotes keratinocyte migration through FAK and Rac1 activation</a><br/>J Nat Med. 2015&emsp;&emsp;PMID:&nbsp;25783411</td><tr/>
<tr><td><strong>124.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26109451/” target=”_blank” rel=”noopener”>A bibenzyl from Dendrobium ellipsophyllum inhibits migration in lung cancer cells </a><br/>Journal of Natural Medicines. 2015&emsp;&emsp;PMID:&nbsp;26109451</td><tr/>
<tr><td><strong>125.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510974/” target=” blank” rel=”noopener”>A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration</a><br/>Nat Commun. 2015&emsp;&emsp;PMID:&nbsp;26166433</td><tr/>
<tr><td><strong>126.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/26035691/” target=”_blank” rel=”noopener”>Depletion of histone deacetylase 1 inhibits metastatic abilities of gastric cancer cells by regulating the miR-34a/CD44 pathway</a><br/>Oncology. 2015&emsp;&emsp;PMID:&nbsp;26035691</td><tr/>
<tr><td><strong>127.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25866159/” target=”_blank” rel=”noopener”>piggyBac Insertional Mutagenesis Screen Identifies a Role for Nuclear RHOA in Human ES Cell Differentiation</a><br/>Stem Cell Reports&#44;2015&emsp;&emsp;PMID:&nbsp;25866159</td><tr/>
<tr><td><strong>128.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25503138/” target=”_blank” rel=”noopener”>Cisplatin at Sub-toxic Levels Mediates Integrin Switch in Lung Cancer Cells</a><br/>Anticancer Research. 2014&emsp;&emsp;PMID:&nbsp;25503138</td><tr/>
<tr><td><strong>129.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24447566/” target=”_blank” rel=”noopener”>Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases</a><br/>Biochimica et Biophysica Acta (BBA) – General Subjects. 2014&emsp;&emsp;PMID:&nbsp;24447566</td><tr/>
<tr><td><strong>130.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24902944/” target=” blank” rel=”noopener”>The glucocorticoid dexamethasone inhibits U937 cell adhesion and neutrophil release via RhoA/ROCK1-dependent and independent pathways</a><br/>Cell Physiol Biochem. 2014&emsp;&emsp;PMID:&nbsp;24902944</td><tr/>
<tr><td><strong>131.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25022961/” target=”_blank” rel=”noopener”>MIF inhibits monocytic movement through a non-canonical receptor and disruption of temporal Rho GTPase activities in U-937 cells</a><br/>Cytokine. 2014&emsp;&emsp;PMID:&nbsp;25022961</td><tr/>
<tr><td><strong>132.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900538/” target=”_blank” rel=”noopener”>Podocyte-specific GLUT4 deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy</a><br/>Diabetes. 2014&emsp;&emsp;PMID:&nbsp;24101677</td><tr/>
<tr><td><strong>133.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24972930/” target=” blank” rel=”noopener”>ARGS5 promotes arterial growth during arteriogenesis</a><br/>EMBO Mol Med. 2014&emsp;&emsp;PMID:&nbsp;24972930</td><tr/>
<tr><td><strong>134.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154134/” target=”_blank” rel=”noopener”>RGS5 promotes arterial growth during arteriogenesis</a><br/>EMBO Mol Med. 2014&emsp;&emsp;PMID:&nbsp;24972930</td><tr/>
<tr><td><strong>135.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24859471/” target=” blank” rel=”noopener”>Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells</a><br/>Int J Oncol. 2014&emsp;&emsp;PMID:&nbsp;24859471</td><tr/>
<tr><td><strong>136.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24463819/” target=”_blank” rel=”noopener”>Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours</a><br/>J Cell Sci. 2014&emsp;&emsp;PMID:&nbsp;24463819</td><tr/>
<tr><td><strong>137.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24610943/” target=” blank” rel=”noopener”>Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells</a><br/>J Cell Sci. 2014&emsp;&emsp;PMID:&nbsp;24610943</td><tr/>
<tr><td><strong>138.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/25329306/” target=”_blank” rel=”noopener”>Triclosan Potentiates Epithelial-To-Mesenchymal Transition in Anoikis-Resistant Human Lung Cancer Cells</a><br/>PLoS One. 2014&emsp;&emsp;PMID:&nbsp;25329306</td><tr/>
<tr><td><strong>139.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23645207/” target=”_blank” rel=”noopener”>Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis</a><br/>Cell Death and Differentiation. 2013&emsp;&emsp;PMID:&nbsp;23645207</td><tr/>
<tr><td><strong>140.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824649/” target=”_blank” rel=”noopener”>Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial–mesenchymal transition of cancer cells</a><br/>Cell Death and Disease&#44;2013&emsp;&emsp;PMID:&nbsp;24113182</td><tr/>
<tr><td><strong>141.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23550588/” target=”_blank” rel=”noopener”>Transgenesis of the Wolffian duct visualizes dynamic behavior of cells undergoing tubulogenesis in vivo</a><br/>Dev Growth Differ. 2013&emsp;&emsp;PMID:&nbsp;23550588</td><tr/>
<tr><td><strong>142.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806621/” target=”_blank” rel=”noopener”>Cyclodextrin protects podocytes in diabetic kidney disease</a><br/>Diabetes. 2013&emsp;&emsp;PMID:&nbsp;23835338</td><tr/>
<tr><td><strong>143.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711289/” target=”_blank” rel=”noopener”>N-glycosylation induces collagen triple helix repeat containing 1 (CTHRC1) and drives oral cancer cell migration</a><br/>J Biol Chem. 2013&emsp;&emsp;PMID:&nbsp;23703614</td><tr/>
<tr><td><strong>144.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/24368807/” target=” blank” rel=”noopener”>JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation</a><br/>J Cell Biol. 2013&emsp;&emsp;PMID:&nbsp;24368807</td><tr/>
<tr><td><strong>145.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/23895422/” target=” blank” rel=”noopener”>Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway</a><br/>J Neurochem. 2013&emsp;&emsp;PMID:&nbsp;23895422</td><tr/>
<tr><td><strong>146.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716611/” target=” blank” rel=”noopener”>MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex</a><br/>PLoS One. 2013&emsp;&emsp;PMID:&nbsp;23894602</td><tr/>
<tr><td><strong>147.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22505643/” target=”_blank” rel=”noopener”>Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats</a><br/>Am J Physiol Heart Circ Physiol. 2012&emsp;&emsp;PMID:&nbsp;22505643</td><tr/>
<tr><td><strong>148.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21900451/” target=”_blank” rel=”noopener”>WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization</a><br/>Am J Physiol Renal Physiol. 2012&emsp;&emsp;PMID:&nbsp;21900451</td><tr/>
<tr><td><strong>149.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22717125/” target=”_blank” rel=”noopener”>Invadopodia and rolling-type motility are specific features of highly invasive p190(bcr-abl) leukemic cells</a><br/>Eur J Cell Biol. 2012&emsp;&emsp;PMID:&nbsp;22717125</td><tr/>
<tr><td><strong>150.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22514275/” target=”_blank” rel=”noopener”>LINGO-1.a transmembrane signaling protein.inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions</a><br/>J Biol Chem. 2012&emsp;&emsp;PMID:&nbsp;22514275</td><tr/>
<tr><td><strong>151.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22923615/” target=”_blank” rel=”noopener”>Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth</a><br/>J Biol Chem. 2012&emsp;&emsp;PMID:&nbsp;22923615</td><tr/>
<tr><td><strong>152.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22573889/” target=”_blank” rel=”noopener”>A role for myosin IXb.a motor-RhoGAP chimera.in epithelial wound healing and tight junction regulation</a><br/>Mol Biol Cell. 2012&emsp;&emsp;PMID:&nbsp;22573889</td><tr/>
<tr><td><strong>153.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22983395/” target=” blank” rel=”noopener”>Endothelial PI3K-C2à.a class II PI3K.has an essential role in angiogenesis and vascular barrier function</a><br/>Nat Med. 2012&emsp;&emsp;PMID:&nbsp;22983395</td><tr/>
<tr><td><strong>154.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271155″ target=”_blank” rel=”noopener”>C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury</a><br/>Neurotherapeutics. 2012&emsp;&emsp;PMID:&nbsp;21866396</td><tr/>
<tr><td><strong>155.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/22139079/” target=”_blank” rel=”noopener”>The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1</a><br/>Oncogene. 2012&emsp;&emsp;PMID:&nbsp;22139079</td><tr/>
<tr><td><strong>156.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338794″ target=”_blank” rel=”noopener”>ProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA</a><br/>PLoS One. 2012&emsp;&emsp;PMID:&nbsp;22558255</td><tr/>
<tr><td><strong>157.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277110″ target=”_blank” rel=”noopener”>Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation</a><br/>Proc Natl Acad Sci U S A. 2012&emsp;&emsp;PMID:&nbsp;22307599</td><tr/>
<tr><td><strong>158.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21036919/” target=”_blank” rel=”noopener”>Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42</a><br/>Am J Physiol Lung Cell Mol Physiol. 2011&emsp;&emsp;PMID:&nbsp;21036919</td><tr/>
<tr><td><strong>159.&emsp;</strong><a href=”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062424″ target=”_blank” rel=”noopener”>Asymmetric Mbc.active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in Drosophila</a><br/>Development. 2011&emsp;&emsp;PMID:&nbsp;21389053</td><tr/>
<tr><td><strong>160.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/21985251/” target=”_blank” rel=”noopener”>Ethanol increases p190RhoGAP activity.leading to actin cytoskeleton rearrangements</a><br/>J Neurochem. 2011&emsp;&emsp;PMID:&nbsp;21985251</td><tr/>
<tr><td><strong>161.&emsp;</strong><a href=”https://pubmed.ncbi.nlm.nih.gov/20478922/” target=”_blank” rel=”noopener”>G(alpha)12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation</a><br/>Carcinogenesis. 2010&emsp;&emsp;PMID:&nbsp;20478922</td><tr/>
</tbody>
</table>